Studies

CellWell record HH-123194

Adaptive changes in adrenal steroid metabolism under extreme physical and psychological stress: a narrative review

Daria Borakowska; Rafał Podgórski; Edyta Łuszczki

2026

In plain language

This review synthesizes how extreme physical and psychological stress, common in military settings, alters HPA axis glucocorticoid pulsatility and flattens circadian cortisol, DHEA-S, and aldosterone patterns, impairing reproductive and metabolic function.

Evidence
Emerging
Design
Expert review

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