Studies

CellWell record HH-120651

Synaptic Actions of Estradiol in the Brain's Reward System: Linking Mechanisms to Behavior and Disease

M Victoria LaChapelle-Sproat; Nicholas S Anderson; Tara A LeGates

2026

In plain language

Estradiol modulates dopamine and opioid receptor expression in reward circuits, influencing reward sensitivity and mood regulation through multiple synaptic mechanisms in sex-specific ways.

Evidence
Emerging
Design
Expert review

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