CellWell record HH-119852
Oxidative Stress and SIRT1-Nrf2 Anti-Ferroptotic Pathways in Granulosa Cells: A Molecular Key to Follicular Atresia and Ovarian Aging
Charalampos Voros; Fotios Chatzinikolaou; Georgios Papadimas; Spyridon Polykalas; Despoina Mavrogianni; Aristotelis-Marios Koulakmanidis; Diamantis Athanasiou; Vasiliki Kanaka; Kyriakos Bananis; Antonia Athanasiou; Aikaterini Athanasiou; Ioannis Papapanagiotou; Charalampos Tsimpoukelis; Athanasios Karpouzos; Maria Anastasia Daskalaki; Nikolaos Kanakas; Marianna Theodora; Nikolaos Thomakos; Panagiotis Antsaklis; Dimitrios Loutradis; Georgios Daskalakis
2026
In plain language
Granulosa cell ferroptosis via oxidative stress and iron dysregulation drives ovarian aging; SIRT1-Nrf2 axis activation through resveratrol and melatonin restores mitochondrial biogenesis and antioxidant defenses.
- Evidence
- Emerging
- Design
- Expert review
Cite this record: https://thecellwell.org/studies/HH-119852
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