CellWell record HH-104603
Arterial Elastin Abundance, Rather Than Orthologue Origin, Modulates Medial Arterial Calcification in Matrix Gla Protein-Deficient Mice
Juliana Marulanda; Ophélie Gourgas; Abhinav Parashar; Robert P. Mecham; Elaine C. Davis; Marta Cerruti; Juergen Brinckmann; Monzur Murshed
2026
In plain language
In MGP-deficient mice, 40% reduction in arterial elastin prevented early-stage medial calcification, with mouse and human elastin orthologues showing comparable effects on calcification progression.
- Evidence
- Emerging
- Design
- Preprint
Cite this record: https://thecellwell.org/studies/HH-104603
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