CellWell record HH-102893
Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
Nemeth E; Tuttle MS; Powelson J; Vaughn MB; Donovan A; Ward DM; Ganz T; Kaplan J
Science (New York, N.Y.) ยท 2004
In plain language
In cultured cells, researchers found that the hormone hepcidin bound directly to the iron exporter ferroportin, causing it to be pulled inside the cell and broken down, which reduced how much iron the cell could release.
- Evidence
- Emerging
Cite this record: https://thecellwell.org/studies/HH-102893
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