CellWell record HH-102326
Activating Cannabinoid receptor 2 alleviates iron overload-induced liver damage via dual modulation of STAT3/hepcidin and Nrf2/FPN1 pathways
Han Deng; Yuqian Ren; Yunjie Sui; Zegang Ma
2026
In plain language
In an iron-overload mouse model, activating cannabinoid receptor 2 reduced liver iron buildup, oxidative stress, and inflammation by suppressing STAT3-driven hepcidin and boosting the iron exporter ferroportin, while removing the receptor made iron accumulation and liver damage worse.
- Evidence
- Emerging
Cite this record: https://thecellwell.org/studies/HH-102326
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