CellWell record HH-102001
Orthostatic Dysfunction and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Close Reciprocal Relationship Beyond Cardiac Preload Failure and Hypoperfusion
Klaus Wirth
2026
In plain language
A hypothesis paper proposes that in ME/CFS, standing triggers sodium buildup and potassium loss inside muscle cells via impaired adrenaline receptor signaling, potentially lowering the threshold for post-exertional crashes independent of blood flow.
- Evidence
- Emerging
- Design
- Preprint
Cite this record: https://thecellwell.org/studies/HH-102001
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